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Corresponding Author
deis hikmawati

Institutions
Fakultas Kedokteran Universitas Islam Bandung

Abstract
Melasma is a predominant hyper melanosis disorder on the face, which is often experienced by middle-aged women. Melasma occurs due to the excessive melanin formation process. The target of melasma therapy is to inhibit melanocyte proliferation and melanosome formation, also increase melanosome degradation. The decreasing of the inflammatory response is a way to inhibit melanin formation. Conventional melasma therapy has some side effects such as erythema and burning, ochronosis, also depigmentation such as confetti. One of the natural ingredients that have the potential to be developed as anti melasma is aloe vera. This study aims to analyze the potential and target of Aloe vera protein as anti melasma. This study uses the In silico method using the pathway analysis method with Pubchem Software, Swiss Target Prediction, String and Cystoscope. The results show that of the many phytochemicals present in aloe, several phytochemical compounds are predicted to act and inhibit the formation of melanin Tyrosinase-related protein1 (TYRP1), EStrogen Receptor 1 (ESR1), Interleukin 10 (IL10), and inducible NO synthase INOS. The conclusion is in silico analysis, the active substance contained can inhibit the enzyme TYR1, and increase IL10 and suppress ESR1 and INOS.

Keywords
Keywords: Aloe vera, antimelasma, in silico, target protein tyrosinase,

Topic
Biopharmaceutical Product and Engineering

Link: https://ifory.id/abstract/x3WmVYf7rjBG

Corresponding Author
Siti Annisa Devi Trusda

Institutions
a)Biochemistry Department, Faculty of Medicine, Universitas Islam Bandung
Tamansari 22, Bandung, Indonesia, trusda_75[at]yahoo.com
b) Public Health Department, Faculty of Medicine, Universitas Islam Bandung
c) Histology Department, Faculty of Medicine, Universitas Islam Bandung
d) Physiology Department, Faculty of Medicine, Universitas Islam Bandung

Abstract
Introduction: Liver cancer is the sixth most common cancer and also the third highest cause of death caused by cancer. Failure in default therapy, side effects, and expensive cancer therapy lead researchers to be encouraged to look for effective and selective new cancer therapies. The aim of this study were to explored the effect of flavonoid active compound from clove leaf oil on liver cancer cells and its combination with standard drug for cancer therapy. Method: The cytotoxicity of active compound isolated from clove leaf oil and standard drug were analyzed on liver cancer cell culture and examines by MTT assay. The drug combination synergisms were indicated by the combination index (CI) using CompuSyn 1.4. Result: The results showed that flavonoid active compound from clove leaf oil in combination standard drug have Combinations Index below 1. Conclusion: It was concluded that flavonoid active compound from clove leaf oil were shown to have anticancer activity on liver cells culture and also have synergistic effect in combination with standard drug for cancer therapy.

Keywords
clove leaf, combination index, cytotoxic activity, flavonoid, liver cancer

Topic
Biopharmaceutical Product and Engineering

Link: https://ifory.id/abstract/rgWfUdKwXTYk

Corresponding Author
Sani Ega Priani

Institutions
Pharmacy Department, Bandung Islamic University (UNISBA)

Abstract
Cocoa pod husk containing polyphenol compounds that have many beneficial activities for topical application. Phytosome is complex between water soluble phytoconstituent like polyphenol with phospholipid that known could enhance its oral and topical penetrations. The objective of this research is to determine the effect of phytosomal system to polyphenol skin penetration from topical serum preparation containing cocoa pod husk extract. Phytosome complex was made using thin layer hydration method at comparison of extract and phospolipid 1:1. The phytosome complex then developed to topical serum preparation. Skin penetration of polyphenol compounds were determined using franz diffusion cell. The results showed that phytosome system could enhance polyphenol skin penetration from the penetration that significantly different with non-phytosomal system (P<0.05).

Keywords
Polyphenol, Skin pentration, Phytosome, Cocoa pod husk

Topic
Biopharmaceutical Product and Engineering

Link: https://ifory.id/abstract/DWZjQgmChVJ2